WP
1_1
- Size of body fat compartments and features of the metabolic syndrome and differential gene expression in adipose tissue and skeletal muscles in adult humans

- Institute of Preventive Medicine

The project looks into whether or not there is a connection between the intake of certain nutrients, amongst other 'bad' and 'good' fatty acids, and the development of obesity. Does it have an impact to consume for example ruminant trans fatty acids on the development of obesity, the metabolic syndrome (disturbances in fat- and sugarmetabolism) or inflammation in adipose tissue? These are the questions asked in this project.

WP
1_2
- Interplay between dietary intake of fatty acids and milk proteins and genetic predisposition to obesity and the metabolic syndrome - using twin studies

- Institute of Preventive Medicine

The project looks into whether or not there is a connection between genetic disposition and the intake of certain nutrients, amongst other 'bad' and 'good' fatty acids. Do these combined have an impact on the development of obesity, the metabolic syndrome (disturbances in fat- and sugarmetabolism) or inflammation in adipose tissue? These are the questions asked in this project.

WP
1_3
- Gene-diet interactions in obesity (GENDINOB)

- Institute of Preventive Medicine

It is clear that the development of obesity cannot be adequately explained as just a lasting enforced positive energy balance. Much more complex interacting mechanisms are operating making predictions based on energy balance difficult if at all possible: appetite (hunger and satiety), energy metabolism, physical activity, body fat distribution (abdominal versus lower body), development of adipose tissue, regulation of fatty acids deposition and release, and synthesis and secretion of regulatory substances from this tissue. This study hypothesizes, that inter-individual differences on body weight gain (including resistance to weight loss and risk of weight regain after weight loss), and in the responses to dietary interventions may originate in genes in which variants lead to different susceptibility to various dietary factors.

WP
2_1
- Dietary nutrients in relation to changes in weight, insulin resistance, lipids and blood pressure

- Institute of Preventive Medicine

This project looks into whether or not is has relevance to the development of obesity, hypertension, hyperlipedmia and diabetes that a person consumes a diet with a low amount of nutrients with a certein functionality. The study is carried out on the basis of records of food intake in larger population groups and focuses on dairy products with fatty acids and certain milk proteins.

WP
2_2
- An analysis of biological material for the fat content in dairy products in selected cohort

- Institute of Preventive Medicine

The project consists of analyses of biological material (blood) in order to compare estimates of fat intake through dairy products.

WP3 - Effect of trans fatty acids on body fat distribution and features of the metabolic syndrome in overweight women - a double blind randomized human study

- University of Copenhagen

This study compares the effect of a diet with a high content of trans fatty acids from partially hydrogenated soybean oil with a diet containing no trans fatty acids. Which effect do the intake of trans fatty acids have on the development of abdominal obesity, diabetes and cardiovascular disease? These are the questions asked in this study.

WP4 - Essential fatty acids in early life nutrition - possible implications for risk of obesity and metabolic complications later in life

- University of Copenhagen

This project looks at the effect of fishoil supplementation on growth, body composition and health in infancy. The general idea is that early life may represent an important window for manipulation of the intestinal microbiota e.g. through the diet. Bacteria entering the gut in early life may favour their own growth and inhibit the growth of other bacteria introduced later in infancy/childhood. Therefore, the early colonisation of the intestinal tract may be of vital importance for the composition of the stable microbiota later in life.

WP5 - Food consumption behaviour and cost-benefit analysis

- University of Copenhagen

This project investigates what has been consumed and purchased of foods containing certain fatty acids in Denmark in recent time. The idea is to cataloque individual dietary habits and food purchase behaviour and to determine the consumers’ responsiveness to changes in the economic conditions. Furthermore, it is the objective to assess the economic benefits and costs of various obesity-preventing intervention strategies.

WP
7_1
- Endocrine response mechanisms, secretion, localisation and function of receptors, and metabolism of the satiety hormones in isolated organs and transgenic mouse models

- University of Copenhagen

For several of the satiety hormones, their mechanism of action seems to involve transmission via vagal sensory afferents. In this project expression of receptors are investigated in the nodose ganglion as well as in the brain stem. Furthermore, this mode of action are investigated for PP, GLP-2 and Ghrelin in pig models of afferent vagus activity.

WP
7_2
- Endocrine regulation involving fatty acids and milk protein and measurement of appetite, feeding initiation and satiety and correlating these to fasting and postprandial circulating levels of ghrelin, PP, CCK, GIP, PYY, GLP-1 and GLP-2

- University of Copenhagen

Certain hormones in the human digestive system work as a feedback to the brain when a person eats. Some regulate the satiety feeling, others regulate the secretion of insulin which is important for a person's glucose tolerance and thereby the possiblity of diabetes. This study looks at what happens with these hormones after a meal containing fatty acids and/or milk proteins.

WP8 - Historical analyses of consumption of foods 1900-2000 in Denmark

- University of Copenhagen

No description available

WP9 - Exploratory metabolomic profiles in humans with various forms and degrees of obesity and metabolic syndrome components

- University of Copenhagen

This project focusses on biomarkers. A biomarker is a an indicator of a biological state. In medicine a biomarker is understood as an indicator of an abnormal state in the human body which is either caused by a disease or drug. High blood pressure for example is seen as a biomarker for the risk of stroke.
This project looks for new biomarkers marking the intake of trans fatty acids and their relation to metabolic changes, advancing obesity and to the metabolic syndrome. When consuming trans fatty acids, do any biomarkers exist that indicate the risk of obesity and related diseases. A second part of this project looks for such markers in samples collected and analyzed from the Diet, Cancer and Health cohort and to relate them with possible disease outcomes. This project relates to other DanORC projects headed by professor Kim Overvad.

WP10 - Interaction between variation in genes and these phenotypes

- Hagedorn Research Institute

No description available

WP
11_1
- PKA-dependent and Epac-dependent pathways of cAMP signaling in adipose tissue, liver and muscle, and the interplay between PUFA, TFA, carbohydrates and proteins in these functions.

- University of Copenhagen

This study investigates how the intake of carbohydrates and proteins impact the way in which polyunsaturated fatty acids influence the metabolism and hereby the development of adipose tissue and obesity. It is also the aim to look at the impact of peptides in dairy products on the metabolism and lastely how different dietary intake of fatty acids, carbohydrates and protein influence the gut microflora. 

WP
11_2
- Novel biomarkers for obesity - the gut microbiome and microparticles as novel biomarkers for obesity

- University of Copenhagen

This project represents an analysis of alterations in the gut microbiome in response to intake of different kind of nutrients by using the novel large scale sequencing capacity of Solexa sequencers.

WP12 - Effects of dietary fatty acids and bioactive polyphenols (e.g. resveratrol) on the obese state and inflammation. Investigations of the effects of fatty acids and polyphenols on adipocytes, macrophages and hepatocytes – gene expression and protenomics

- Aarhus University

This project investigates  the biological impact of dietary fatty acids on a cellular level and their interactions with polyphenols. The idea is that various dietary fatty acids may have important (and opposite) effects on the development of adipose tissue and the chronic low-grade inflammation state of adipose tissue which is seen in obese persons and, moreover, polyphenols may antagonize some of the negative effects of fatty acids.

WP13 - Effects of dietary protein on postprandial lipaemia (PLL) in obese and type 2 diabetic

- Aarhus University

The overall aim is to analyze how the protein quality in general and milk proteins in particular in food influence the amount and composition of fat in the blood after a meal and what impact milk proteins have on the blood coagulation, i.a. ability to clot. This is of important as it might pose as a risk for cardiovascular heart disease.

WP14 - Impact of dietary intake of fatty acids and milk protein in pregnancy on development of obesity in childhood

- Statens Serum Institute

The project looks at early riskfactors for the development of obesity. The concrete aim is to investigate whether or not the development of obesity in childhood is connected to the mother's intake of certain nutrients during her pregnancy. Does the intake of one nutrient prevent later obesity in the child's life and the intake of another lead later development of obesity? These are the questions asked in this project. The nutrients are omega-3 and omega-6 polyunsaturated fatty acids, trans fatty acids and proteins from milk.

WP
15_1
- Intake of fatty acids and milk proteins and development of cardiovascular disease and diabetes

- Aalborg Hospital / Aarhus University Hospital

The aim of this project is to investigate associations between intake of fatty acids and milk proteins and development of cardiovascular disease and diabetes. 

WP
15_2
- Anthropometry and development of cardiovascular disease, diabetes, and death

- Aalborg Hospital / Aarhus University Hospital

This project investigates the association between changes in weight and waist circumference and the development of cardiovascular disease, diabetes and death.

WP
15_3
- Intake of fatty acids and milk proteins and changes in anthropometry

- Aalborg Hospital / Aarhus University Hospital

The aim of this project is to investigate associations between intake of fatty acids, milk products, and proteins and subsequent changes in body dimensions (anthropometry) in an established large scale prospective population based cohort. 

WP
17_1
- Investigation of the role of casein derived peptides in the modulation of infections and inflammation

- Chr. Hansen A/S

This project looks at the anti-inflammatory effects of biological active peptides in fermented milk or yogurt in cell cultures. The background is the high grade of tissue inflammation in obese persons.

WP
17_2
- Probiotics and satiety – acute effects and persistence of acute effects

- Chr. Hansen A/S

This project looks at to examine the effects of a probiotics on subjective appetite sensation, ad libitum energy intake, and appetite hormone response.

WP - Improving accuracy of contents of polyunsaturated fatty acids and trans fatty acids

- Technical University of Denmark

Accuracy of food composition values is important in the assessment of possible beneficial or adverse effetcs of specific nutrient intakes estimated from dietary intakes. This study aims at improving accuracy of contents of polyunsaturated fatty acids (PUFA) and trans fatty acids (TFA) in selected foods and make it available for the project participants.

DANORC is supported by the
The Danish Council for Strategic Research
Institute of Preventive Medicine
Frederiksberg Hospital
Nordre Fasanvej 57
2000 Frederiksberg
Denmark
Tel.: +45 38163025