Waist Circumference Adjusted for Body Mass Index and Intra-Abdominal Fat Mass

Landsvig Berentzen T; Ängquist L; Kotronen A; Borra R; Yki-Järvinen H; Iozzo P; Parkkola R; Nuutila P; Ross R; Allison DB; Heymsfield S; Overvad K; Sørensen TIA; Uhre Jakobsen M
PLoS One
Paper attributed to Project(s)

Several studies suggest that the association between anthropometric measures of obesity, such as body mass index (BMI) and waist circumference (WC), and mortality is U-shaped [1]–[3]. However, recent large-scale studies have consistently shown that the association between WC and mortality is particularly strong and direct when adjusted for BMI [1], [4]–[8]. The explanation behind this direct association is not established, but one conceivable explanation is that WC adjusted for BMI is a better predictor than WC alone of intra-abdominal fat mass (IAFM), which is presumed to be the most harmful fat depot [9], [10].

We pooled anthropometric and magnetic resonance imaging (MRI) data from European and American samples, and studied the prediction of abdominal subcutaneous fat mass (ASFM) and IAFM by WC alone and by addition of BMI as an explanatory factor.

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